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Toxicology, Physiology, & Cell Biology

Chronic diseases such as COPD, asthma, cancer, pulmonary fibrosis, and cardiovascular diseases are major causes of morbidity and mortality worldwide. Our research is focused on the pathophysiology of these diseases, the discovery of novel molecular mechanisms, and the development of new innovative therapeutic strategies. Opportunities for doctoral student research are related to an understanding of how the environment leads to chronic diseases. There is a strong focus on lung and vascular diseases, but environmental pollutants often lead to toxic pathologies in multiple organs, that are also studied. This mechanistic approach involves several disciplines including immunology, physiology, toxicology, genetics, and epigenetics. Students will obtain a broad education that will enable a long and successful research career.

Research Highlights

Prostate Cancer Cells Become 'Shapeshifters' to Spread to Distant Organs

One of prostate cancer's worst features is its ability to spread to distant sites, particularly bone, and to start new, malignant outposts, and Johns Hopkins researchers have turned up an important clue — and a potential new avenue for treatment. Hopkins scientists report they have discovered a biochemical process that gives prostate cancer cells the almost unnatural ability to change their shape, squeeze into other organs and take root in other parts of the body. The scientists say their cell culture and mouse studies of the process, which involves a cancer-related protein called AIM1, suggest potential ways to intercept or reverse the ability of cancers to metastasize, or spread. Learn more about this cutting-edge research.

Associated Faculty

*Denotes faculty who are accepting PhD students.