Johns Hopkins Lung Diseases Preclinical Animal Model Core
Our mission is to provide environmental exposures to mice, including cigarette smoke, allergens, bacterial/viral pathogens, and electronic cigarette vapor, in order to develop novel therapies.
In the US and globally, there has been a rise in environmental-related diseases, specifically respiratory diseases, due to exposure of environmental toxicants and stressors such as cigarette smoke, other indoor/outdoor air pollutants, respiratory bacteria/viruses and allergens.
Chronic exposure to these environmental agents causes oxidative/nitrosative stress, inflammation, and cell injury, and these pathological processes mediate a diverse set of diseases (specifically COPD and asthma). Susceptibility to environmental toxicants is mediated through a complex interaction of environmental and genetic determinants.
Our facility has unique expertise to allow investigators to assess genetic modifiers of disease susceptibility in response to environmental exposure using mouse models. The main constraint to develop new therapies for treatment of environmentally related diseases is the lack of appropriate preclinical animal models.
Our “Lung Diseases Preclinical Animal Model Core Facility” will provide exposure of mouse models to different environmental toxicants. This research will aid in understanding mechanisms and help in experimental therapeutics (testing and developing innovative therapies) for prevention and treatment of environmental exposure-induced diseases.